Julkaisuarkisto

Background and aims: Substance-induced psychoses (SIP) have the potential to relapse and convert into schizophrenia-spectrum disorders. However, risk factors associated with SIP relapse remain unknown. The aim of this study was to measure the incidence and risk of SIP relapse and associating risk factors.

Design, setting and participants: Population based register study that identified people with first-time SIP between 2006 and 2016 (n = 7320) from Swedish nation-wide registers to examine incidence of relapse and associated risk factors during 2-year follow-up. Participants were censored to death, emigration and the diagnosis of other psychotic illness. Risk factors associated with relapse were studied using multivariable Cox models.

Measurements: SIP was measured via related diagnostic codes (ICD-10: F1x.5) collected from the National Patient Register (NPR). SIP relapse was measured as hospitalization due to SIP during 2-year follow-up also collected from the NPR. Potential risk factors included demographic characteristics, psychiatric comorbidities, sickness absence and disability pension collected from nationwide registers.

Findings: Of the study population (n = 7320), 20.0% (n = 1463) had a SIP relapse during the follow-up (median time 126 days, interquartile range 56-321) and 83.3% had the same type of SIP as their first SIP. Relapse was most common for those whose first SIP was induced by cannabis (25.7%), followed by multi-substance use (23.8%) and (meth)amphetamine (19.7%). Factors associated with SIP relapse were previous substance use disorder [hazard ratio (HR) = 1.37, 95% confidence interval (CI) = 1.20-1.56], younger age (16-29 years, HR = 1.29, 95% CI = 1.05-1.58, versus 50-65), being born abroad (HR = 1.23, 95% CI = 1.07-1.41), attention deficit hyperactivity disorder (HR = 1.21, 95% CI = 1.05-1.39), having had 1-90 days sick leave during the previous year (HR = 1.19, 95% CI = 1.01-1.44), and cannabis- (HR = 2.42, 95% CI = 1.98-2.96), (meth)amphetamine- (HR = 1.49, 95% CI = 1.23-1.81) or multi-substance- (HR = 1.81, 95% CI = 1.52-2.15) induced psychosis compared with alcohol-induced psychosis.

Conclusions: In Sweden, 20% of people with substance-induced psychosis between 2006 and 2016 had a relapse within 2 years follow-up. Cannabis-induced psychosis had the shortest time lapse between episodes. Risk factors for relapse included attention deficit hyperactivity disorder, substance-use disorder, younger age, previous sickness absence and being born outside Sweden.

Political and economic challenges, amplified by social media algorithms, are increasingly polarising how people receive and evaluate information. This study examines how political views and immediate emotional reactions shape the perceived trustworthiness of information. We conducted a preregistered laboratory experiment in which participants evaluated politically charged statements while their emotional responses were assessed in real time. Facial expressions were recorded to identify seven discrete emotions, while galvanic skin response and heart rate were measured to capture physiological arousal and reaction intensity. Consistent with expectations and prior research, we observed a clear political confirmation bias: ideologically congruent statements were rated as more trustworthy, with the strongest effect among the most conservative participants. Increases in anger and sadness were positively associated with trust ratings across the sample, whereas joy was linked to reduced confirmation bias. Among conservatives, multiple emotions predicted overall trust and the extent of confirmation bias. Machine-learning models incorporating physiological data likewise identified anger and joy as the most informative emotional predictors; however, physiological measures did not improve predictive performance beyond the baseline model, contrary to our expectation. By integrating behavioural and real-time physiological measures, the findings highlight how emotional and cognitive processes interact to shape trust in political information.

Lactic fermentation enhances sensory quality and nutritional properties of fruit juice, though its comprehensive impact on sea buckthorn through Lactiplantibacillus plantarum fermentation (LPF) remains unreported. This study used volatolomics and metabolomics to explore mechanism of lactic fermentation improving flavor. LPF reduced total acidity (from 24.01 g/L to 15.79 g/L), increased total flavonoid by 20.35% and polysaccharide contents by 55.64%. It also increased the quantity of volatile compounds (from 36 to 41). β-Damascenone and ethyl isovalerate were key aroma compounds, while the increase of phenylethyl alcohol and phenylacetaldehyde improved sweet, fruity, and floral aroma. The rise of adenosine, hypoxanthine, and ornithine through purine metabolism pathways enhanced umami, the enlargement of pyridoxine, pyridoxamine, and tyramine through Vitamin B6 and tyrosine metabolism pathways increased richness, and the elevated glycyrrhizin, melezitose, and maltotetraose enhanced sweetness. This study provides insight into improving sea buckthorn flavor and direction to produce high quality products.

Keywords: Lactic fermentation; Metabolic pathways; Metabolomics; Sea buckthorn; Volatile compounds.

Background:

Studies indicate that alterations in gut microbiota composition (GMC) during the first 1,000 days of life are associated with neurodevelopment and further behavioral development. However, research on the associations between GMC and executive functions (EFs) in childhood is scarce. This study aims to improve the understanding of the biological processes underlying behavioral development by exploring the associations between GMC and EFs early in life.

Methods:

Study population (n = 373) is part of the longitudinal FinnBrain Birth Cohort Study. GMC was analyzed using infant and toddler stool sample 16S rRNA sequencing and targeted and untargeted metabolomic assays. EF was assessed using the Spin the Pots and Snack Delay tasks at 2.5 years and the Spin the Pots task, Delay of Gratification task, EF Touch battery and BRIEF-2 questionnaire at 5 years.

Conclusions:

Alpha diversity in infancy was negatively associated with preschool EF. Additionally, EFs differed between microbial groups based on dominant genera. Bacterial genera abundances were related to some EFs, but no associations were found between microbial metabolites and EF. This study is among the first to investigate associations between GMC and EF in childhood, a crucial developmental stage characterized by significant changes in both the brain and microbiota.

Objectives: The aim was to evaluate the association between public oral healthcare procedures and change in oral health-related quality of life (OHRQoL) over four years among parents in the FinnBrain Cohort Study, comparing those who did not visit public oral healthcare.

Methods: Study used data on parents of young children from the FinnBrain Birth Cohort Study (www.finnbrain.fi) and healthcare centers’ national patient data register. OHRQoL was measured with the 14-item Oral Health Impact Profile (OHIP-14). Of those who had answered the OHIP-14 questionnaire at gestational week (gw) 34 and 4-year time points (n=1552), 589 had visited a public oral healthcare service. OHIP-14 severity score, two thresholds of prevalence and their changes were evaluated according to gender and public oral healthcare visits (Mann-Whitney U test, ꭓ² test, Wilcoxon signed ranks test). Correlations between treatment procedures and OHRQoL were evaluated among those who had visited public oral healthcare service. Association between OHRQoL and its change with different treatment procedures were evaluated by using Spearman correlation coefficients.

Results: OHRQoL did not change for the majority of parents, regardless of visiting public oral healthcare services, or if they received oral healthcare treatment or only preventive procedures. Change in OHRQoL and treatment procedures showed a weak association. OHRQoL worsened most for those receiving treatment in four or more procedure groups. Changes in OHRQoL were not clinically meaningful.

Conclusions: Oral healthcare procedures seem to have a limited impact on OHRQoL changes among parents of young children.