Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry
Pedro Carrilho-Ferreira; Yoshio Kobayashi; Stephan B. Felix; Michel Noutsias; Wolfgang Rottbauer; Filippo Crea; Holger Thiele; Roman Pfister; Richard Kobza; Jennifer Franke; Lawrence Rajan; Burkert M. Pieske; Mikhail Gilyarov; Adrian Banning; Michael Böhm; Leonarda Galiuto; Charanjit S. Rihal; Christina Chan; Gerd Hasenfuß; Ibrahim El-Battrawy; Claudius Jacobshagen; Clément Delmas; Petr Widimsky; Alexandra Shilova; Maike Knorr; Paul Bridgman; Guido Michels; Florim Cuculi; Susanne Heiner; Jose David Arroja; Wolfgang Koenig; Rafal Dworakowski; Christof Burgdorf; Stjepan Jurisic; Konrad A. Szawan; Claudio Bilato; Milosz Jaguszewski; Ekaterina Gilyarova; Tuija Vasankari; Petr Tousek; Thomas F. Lüscher; Wolfgang Dichtl; Daniel Beug; Rodolfo Citro; Jelena R. Ghadri; Hugo A. Katus; Eduardo Bossone; Fabrizio D’Ascenzo; Ibrahim Akin; Alexander Pott; Gregor Poglajen; L. Christian Napp; Mahir Karakas; Christoph Kaiser; Heribert Schunkert; Stefan Osswald; Philip MacCarthy; Ruediger C. Braun-Dullaeus; David E. Winchester; Abhiram Prasad; Sebastiano Gili; Carlo Di Mario; K. E. Juhani Airaksinen; Philippe Meyer; Christian Ukena; Grzegorz Opolski; Thomas A. Fischer; Fausto J. Pinto; Martin Kozel; Johann Bauersachs; Behrouz Kherad; Victoria L. Cammann; Jeroen J. Bax; Jan Galuszka; Christian Templin; Thomas Münzel; Martin Borggrefe; Frank Ruschitzka; Alessandro Cuneo; Carla Paolini; Olivier Lairez; Carsten Tschöpe; John D. Horowitz; Annahita Sarcon; Ken Kato
Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry
WILEY
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042821106
https://urn.fi/URN:NBN:fi-fe2021042821106
Tiivistelmä
Background-Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients.Methods and Results-TTS patients from the International Takotsubo Registry were included in this study. Cut-off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In-hospital outcomes and 1-year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early LV recovery and 215 (53.0%) demonstrated late LV improvement. Patients without early recovery were more often male (12.6% versus 5.2%; P=0.011) and presented more frequently with typical TTS (76.3% versus 67.0%, P=0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1-year outcome compared with patients with early recovery (P=0.003). On multiple logistic regression, male sex, LV ejection fraction <45%, and acute neurologic disorders were associated with the absence of early recovery.Conclusions-TTS patients without early LV recovery have different clinical characteristics and less favorable 1-year outcome compared with patients with early recovery. The factors associated with the absence of early recovery included male sex, reduced LV ejection fraction, and acute neurologic events.
Kokoelmat
- Rinnakkaistallenteet [19207]