Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia
Katri Räikkonen; Stefan R. Hansson; Pia M. Villa; Grigorios Kalapotharakos; Bo Åkerström; Tero Vahlberg; Esa Hämäläinen; Katja Murtoniemi; Hannele Laivuori; Eero Kajantie
https://urn.fi/URN:NBN:fi-fe2021042825098
Tiivistelmä
Recent studies have shown increased concentration of fetal hemoglobin
(HbF) in pre-eclamptic women. Plasma hemopexin (Hpx) and
alpha-1-microglobulin (A1M) are hemoglobin scavenger proteins that
protect against toxic effects of free heme released in the hemoglobin
degradation process. We used an enzyme-linked immunosorbent assay to
analyze maternal plasma Hpx and A1M concentrations at 12–14, 18–20 and
26–28 weeks of gestation in three groups: 1) 51 women with a low risk
for pre-eclampsia (LRW), 2) 49 women with a high risk for pre-eclampsia
(PE) who did not develop PE (HRW) and 3) 42 women with a high risk for
PE who developed PE (HRPE). The study had three aims: 1) to investigate
whether longitudinal differences exist between study groups, 2) to
examine if Hpx and A1M concentrations develop differently in
pre-eclamptic women with small for gestational age (SGA) fetuses vs.
pre-eclamptic women with appropriate for gestational age fetuses, and 3)
to examine if longitudinal Hpx and A1M profiles differ by PE subtype
(early-onset vs. late-onset and severe vs. non-severe PE). Repeated
measures analysis of variance was used to analyze differences in Hpx and
A1M concentrations between the groups. We found that the differences in
longitudinal plasma Hpx and A1M concentrations in HRW compared to HRPE
and to LRW may be associated with reduced risk of PE regardless of
clinical risk factors. In women who developed PE, a high A1M
concentration from midgestation to late second trimester was associated
with SGA. There were no differences in longitudinal Hpx and A1M
concentrations from first to late second trimester in high-risk women
who developed early-onset or. late-onset PE or in women who developed
severe or. non-severe PE.
Kokoelmat
- Rinnakkaistallenteet [19207]