Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Hubert Dirven; Partho Sen; Karin Zimmer; Johanna Bodin; Unni C Nygaard; Dawei Geng; Tuulia Hyotylainen; Matej Oresic; Alex M Dickens; Santosh Lamichhane; Heli Siljander; Tim Sinioja; Jorma Ilonen; Hanne F Bentsen; Daniel Duberg; Cecilia Carlsson; Mikael Knip; Aidan McGlinchey; Suvi M Virtanen
Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Hubert Dirven
Partho Sen
Karin Zimmer
Johanna Bodin
Unni C Nygaard
Dawei Geng
Tuulia Hyotylainen
Matej Oresic
Alex M Dickens
Santosh Lamichhane
Heli Siljander
Tim Sinioja
Jorma Ilonen
Hanne F Bentsen
Daniel Duberg
Cecilia Carlsson
Mikael Knip
Aidan McGlinchey
Suvi M Virtanen
Katso/Avaa
Lataukset: 

Elsevier
doi:10.1016/j.envint.2020.105935
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825103
Tiivistelmä

In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.

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