Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men
Parkkola R; Motiani KK; Jensen J; Loyttyniemi E; Virtanen KA; Din MU; Knuuti J; Eskelinen JJ; Motiani P; Saunavaara V; Middelbeek RJ; Savolainen AM; Kemppainen J; Goodyear LJ; Hannukainen JC; Kalliokoski KK; Nuutila P
Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men
Parkkola R
Motiani KK
Jensen J
Loyttyniemi E
Virtanen KA
Din MU
Knuuti J
Eskelinen JJ
Motiani P
Saunavaara V
Middelbeek RJ
Savolainen AM
Kemppainen J
Goodyear LJ
Hannukainen JC
Kalliokoski KK
Nuutila P
WILEY
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042717212
https://urn.fi/URN:NBN:fi-fe2021042717212
Tiivistelmä
Aims: To test the hypothesis that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) improve brown adipose tissue (BAT) insulin sensitivity.Participants and methods: Healthy middle-aged men (n = 18, age 47 years [95% confidence interval {CI} 49, 43], body mass index 25.3 kg/m(2) [95% CI 24.1-26.3], peak oxygen uptake (VO2peak) 34.8 mL/kg/min [95% CI 32.1, 37.4]) were recruited and randomized into six HIIT or MICT sessions within 2 weeks. Insulin-stimulated glucose uptake was measured using 2-[F-18] flouro-2-deoxy-D-glucose positron-emission tomography in BAT, skeletal muscle, and abdominal and femoral subcutaneous and visceral white adipose tissue (WAT) depots before and after the training interventions.Results: Training improved VO2peak (P =.0005), insulin-stimulated glucose uptake into the quadriceps femoris muscle (P =.0009) and femoral subcutaneous WAT (P =.02) but not into BAT, with no difference between the training modes. Using pre-intervention BAT glucose uptake, we next stratified subjects into high BAT (> 2.9 mu mol/100 g/min; n = 6) or low BAT (< 2.9 mu mol/100 g/min; n = 12) groups. Interestingly, training decreased insulin-stimulated BAT glucose uptake in the high BAT group (4.0 [2.8, 5.5] vs 2.5 [1.7, 3.6]; training*BAT, P =.02), whereas there was no effect of training in the low BAT group (1.5 [1.2, 1.9] vs 1.6 [1.2, 2.0] mu mol/100 g/min). Participants in the high BAT group had lower levels of inflammatory markers compared with those in the low BAT group.Conclusions: Participants with functionally active BAT have an improved metabolic profile compared with those with low BAT activity. Short-term exercise training decreased insulin-stimulated BAT glucose uptake in participants with active BAT, suggesting that training does not work as a potent stimulus for BAT activation.
Kokoelmat
- Rinnakkaistallenteet [19207]