Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Christiani D.; Cybulski C.; Gonzalez-Neira A.; Brenner H.; Robidoux F.; Wiklund F.; Zuber V.; Muir K.; Kote-Jarai Z.; Benitez J.; Hung R.; Offit K.; Humphreys M.; Antoniou A.; Wu X.; Al Olama A.; Stanford J.; Bacot F.; Bojesen S.; Khaw K.; Teixeira M.; Kaneva R.; Nielsen S.; Dennis J.; Travis R.; Tessier D.; Blot W.; Mills I.; Ye Y.; Pandha H.; Benlloch S.; Caporaso N.; Kibel A.; McGuffog L.; Haiman C.; Heinrich J.; Giles G.; Landi M.; Brennan P.; Wang Q.; Andreassen O.; Cunningham J.; Urbanucci A.; Gronberg H.; Dunning A.; Weischer M.; Hilker C.; Batra J.; Berchuck A.; Neal D.; Risch A.; Vincent D.; Amos C.; Thibodeau S.; Rosenberger A.; Houlston R.; Simard J.; Maier C.; Michailidou K.; Eeles R.; Witoelar A.; Nordestgaard B.; LaBoissière S.; Lee A.; Luccarini C.; Han Y.; Bolla M.; Pharoah P.; Park J.; Bickeböller H.; Easton D.; Meyer J.; Windebank S.; Bettella F.; Couch F.; Chenevix-Trench G.; Cannon-Albright L.; Schleutker J.; Dicks E.
Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Christiani D.
Cybulski C.
Gonzalez-Neira A.
Brenner H.
Robidoux F.
Wiklund F.
Zuber V.
Muir K.
Kote-Jarai Z.
Benitez J.
Hung R.
Offit K.
Humphreys M.
Antoniou A.
Wu X.
Al Olama A.
Stanford J.
Bacot F.
Bojesen S.
Khaw K.
Teixeira M.
Kaneva R.
Nielsen S.
Dennis J.
Travis R.
Tessier D.
Blot W.
Mills I.
Ye Y.
Pandha H.
Benlloch S.
Caporaso N.
Kibel A.
McGuffog L.
Haiman C.
Heinrich J.
Giles G.
Landi M.
Brennan P.
Wang Q.
Andreassen O.
Cunningham J.
Urbanucci A.
Gronberg H.
Dunning A.
Weischer M.
Hilker C.
Batra J.
Berchuck A.
Neal D.
Risch A.
Vincent D.
Amos C.
Thibodeau S.
Rosenberger A.
Houlston R.
Simard J.
Maier C.
Michailidou K.
Eeles R.
Witoelar A.
Nordestgaard B.
LaBoissière S.
Lee A.
Luccarini C.
Han Y.
Bolla M.
Pharoah P.
Park J.
Bickeböller H.
Easton D.
Meyer J.
Windebank S.
Bettella F.
Couch F.
Chenevix-Trench G.
Cannon-Albright L.
Schleutker J.
Dicks E.
Katso/Avaa
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BioMed Central Ltd.
doi:10.1186/s12864-017-3620-y
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042717829
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Conclusions

This is the first study to evaluate the enrichment of epigenetic readers in genome-wide associations studies for SNPs within enhancers, and provides a powerful tool for enriching and prioritizing PC and BC genetic risk loci. Our study represents a proof of principle applicable to other diseases and traits that can be used to redefine molecular mechanisms of human phenotypic variation.

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