Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma
Akdis Mübeccel; Bachert Claus; Finotto Susetta; Jartti Tuomas; Kiefer Alexander; Koelle Julia; Kowalski Marek L; Krammer Susanne; Lewandowska-Polak Anna; Li Nina; Lukkarinen Heikki; Mirzakhani Hoomann; Papadopoulos Nikolaos G; Raby Benjamin A; Rauh Manfred; Stanic Barbara; Vuorinen Tytti; Weiss Scott T; Xepapadaki Paraskevi; Yang Zuqin; Zhang Nan; Zimmermann Theodor
Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma
Akdis Mübeccel
Bachert Claus
Finotto Susetta
Jartti Tuomas
Kiefer Alexander
Koelle Julia
Kowalski Marek L
Krammer Susanne
Lewandowska-Polak Anna
Li Nina
Lukkarinen Heikki
Mirzakhani Hoomann
Papadopoulos Nikolaos G
Raby Benjamin A
Rauh Manfred
Stanic Barbara
Vuorinen Tytti
Weiss Scott T
Xepapadaki Paraskevi
Yang Zuqin
Zhang Nan
Zimmermann Theodor
CELL PRESS
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021120158415
https://urn.fi/URN:NBN:fi-fe2021120158415
Tiivistelmä
RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.
Kokoelmat
- Rinnakkaistallenteet [19207]