Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies
Eero Kajantie; Hannele Laivuori; Pia Villa; Stefan R. Hansson; Grigorios Kalapotharakos; Katja Murtoniemi; Katri Räikkönen; Bo Åkerström; Esa Hämäläinen
Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies
Eero Kajantie
Hannele Laivuori
Pia Villa
Stefan R. Hansson
Grigorios Kalapotharakos
Katja Murtoniemi
Katri Räikkönen
Bo Åkerström
Esa Hämäläinen
FRONTIERS MEDIA SA
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042827381
https://urn.fi/URN:NBN:fi-fe2021042827381
Tiivistelmä
Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1 -microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.
Kokoelmat
- Rinnakkaistallenteet [19207]