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Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Yuan XW; Liu C; Zhou WH; Cui WG; Qu XM; Wang YH; Zhang HB; Zou HX; Yan JQ; Li ZJ; Ma XD; Rosenholm JM
dc.contributor.authorYuan XW
dc.contributor.authorLiu C
dc.contributor.authorZhou WH
dc.contributor.authorCui WG
dc.contributor.authorQu XM
dc.contributor.authorWang YH
dc.contributor.authorZhang HB
dc.contributor.authorZou HX
dc.contributor.authorYan JQ
dc.contributor.authorLi ZJ
dc.contributor.authorMa XD
dc.contributor.authorRosenholm JM
dc.date.accessioned2022-10-28T13:30:33Z
dc.date.available2022-10-28T13:30:33Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/165670
dc.description.abstractHerein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.
dc.language.isoen
dc.publisherROYAL SOC CHEMISTRY
dc.titleSelf-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy
dc.identifier.urlhttps://doi.org/10.1039/D2BM00640E
dc.identifier.urnURN:NBN:fi-fe2022091258633
dc.relation.volume10
dc.contributor.organizationfi=biotiedekeskuksen yhteiset|en=Biotiedekeskuksen yhteiset|
dc.contributor.organization-code2609200
dc.converis.publication-id176143658
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/176143658
dc.format.pagerange4119
dc.format.pagerange4125
dc.identifier.eissn2047-4849
dc.identifier.jour-issn2047-4830
dc.okm.affiliatedauthorZhang, Hongbo
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline318 Medical biotechnologyen_GB
dc.okm.discipline318 Lääketieteen bioteknologiafi_FI
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.doi10.1039/d2bm00640e
dc.relation.ispartofjournalBiomaterials Science
dc.relation.issue15
dc.year.issued2022


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