Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry
Niederseer David; Karakas Mahir; D’Ascenzo Fabrizio; Levinson Rena A.; Templin Christian; Kobza Richard; Szawan Konrad A.; Carrilho-Ferreira Pedro; Akin Ibrahim; Galiuto Leonarda; Sarcon Annahita; Bossone Eduardo; Schönberger Maximilian; Tousek Petr; Saito Shigeru; Jansen Thomas; Dichtl Wolfgang; Murakami Tsutomu; Shiomura Reiko; Shimizu Wataru; Burgdorf Christof; Seifert Burkhardt; Jacobshagen Claudius; MacCarthy Philip; Crea Filippo; Liu Kan; Cammann Victoria L.; Paolini Carla; Prasad Abhiram; Gilyarov Mikhail; Shilova Alexandra; Banning Adrian; Jaguszewski Milosz; Nakamura Shunichi; Pott Alexander; Ishibashi Iwao; Rajan Lawrence; Cuneo Alessandro; Delmas Clément; Knorr Maike; Napp L. Christian; Bax Jeroen J.; Empen Klaus; Schunkert Heribert; Mizuno Shingo; Borggrefe Martin; Heiner Susanne; Bauersachs Johann; Felix Stephan B.; Widimský Petr; Kozel Martin; Bridgman Paul; Di Vece Davide; Opolski Grzegorz; El-Battrawy Ibrahim; Wakita Masaki; Jörg Lucas; Fischer Thomas A.; Rickli Hans; Lüscher Thomas F.; Maier Lars S.; Bianco Matteo; Airaksinen K. E. Juhani; Di Mario Carlo; Gili Sebastiano; Osswald Stefan; Lairez Olivier; Meyer Philippe; Bilato Claudio; Poglajen Gregor; Franke Jennifer; Kimura Akihisa; Beug Daniel; Kaiser Christoph; Katus Hugo A.; Galuszka Jan; Isogai Toshiaki; Tschöpe Carsten; Winchester David E.; Suzuki Noriko; Noutsias Michel; Hauck Christian; Koenig Wolfgang; Said Samir M.; Vasankari Tuija; Dworakowski Rafal; Rihal Charanjit S.; Kobayashi Yoshio; Dreiding Sara; Shinbane Jerold; Himi Toshiharu; Hasenfuß Gerd; Yamaguchi Tetsuo; Pieske Burkert M.; Pinto Fausto J.; Würdinger Michael; Wischnewsky Manfred; Citro Rodolfo; Imori Yoichi; Böhm Michael; Gilyarova Ekaterina; Michels Guido; Budnik Monika; Ukena Christian; Braun-Dullaeus Ruediger C.; Horowitz John D.; Thiele Holger; Neuhaus Michael; Chan Christina; Cuculi Florim; Kherad Behrouz; Ikari Yuji; Petkova Vanya; Ruschitzka Frank; Mochizuki Hiroki; Münzel Thomas; Tomita Yasuhiro; Rottbauer Wolfgang; Pfister Roman; Arroja Jose David; Ghadri Jelena R.; Takano Hitoshi; Sorici-Barb Ioana; Kato Ken
https://urn.fi/URN:NBN:fi-fe2021093048684
Tiivistelmä
Background
Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes.
Methods
TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients.
Results
A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 +/- 11.4 years vs. 68.0 +/- 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p< 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p< 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients.
Conclusion
Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers.
Kokoelmat
- Rinnakkaistallenteet [19207]