Weight gain in infancy and markers of cardiometabolic health in young adulthood
Pahkala Katja; Viikari Jorma; Salo Pia; Jula Antti; Rönnemaa Tapani; Nummela Saga R; Raitakari Olli T; Rovio Suvi P; Niinikoski Harri
Weight gain in infancy and markers of cardiometabolic health in young adulthood
Pahkala Katja
Viikari Jorma
Salo Pia
Jula Antti
Rönnemaa Tapani
Nummela Saga R
Raitakari Olli T
Rovio Suvi P
Niinikoski Harri
WILEY
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081154638
https://urn.fi/URN:NBN:fi-fe2022081154638
Tiivistelmä
Aim We studied whether repeatedly measured weight gain from birth up to age 2 years associated with cardiometabolic health in young adulthood. Methods Using the data collected in the longitudinal Special Turku Coronary Risk Factor Intervention Project, we investigated in 454 healthy subjects how early weight gain in six age intervals (birth to 7 months, 7-13 months, 13-18 months, 18-24 months, and birth to 13 and 24 months) associated with measures of cardiometabolic health at age 20 years. Linear regression analyses were controlled for (1) child's sex, intervention/control group, gestational age, baseline weight and change in length for each interval, and (2) parents' education, mother's weight before pregnancy, height and weight gain during pregnancy, and father's body mass index at the 7-month visit. Results Weight gain after the first year of life associated directly, when adjusted for traits of the child and parents, with systolic blood pressure, waist circumference and body mass index at age 20 years. In the fully adjusted analyses, weight gain from birth to 1 year and to 2 years of age associated inversely with insulin and insulin resistance. We found no association between early growth and diastolic blood pressure or serum lipids. Conclusion Early weight gain during first 2 years of life may predict later markers of cardiometabolic health.
Kokoelmat
- Rinnakkaistallenteet [19207]