Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort

Ziegler AG; Toppari J; Agardh D; Lernmarklo A; Akolkar B; Sharma A; Rich SS; Liu E; Rewers M; Krischer JP; Simell O; She JX; Teddy Study group; Simell V; Hadley D; Chen WM; Onengut-Gumuscu S; Hagopian W; Liu X
Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort

Ziegler AG
Toppari J
Agardh D
Lernmarklo A
Akolkar B
Sharma A
Rich SS
Liu E
Rewers M
Krischer JP
Simell O
She JX; Teddy Study group
Simell V
Hadley D
Chen WM
Onengut-Gumuscu S
Hagopian W
Liu X
Katso/Avaa
Lataukset: 

PUBLIC LIBRARY SCIENCE
doi:10.1371/journal.pone.0152476
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042714787
Tiivistelmä


In conclusion, using a genetic analysis of a large international cohort of children, we associated celiac disease development with 5 non-HLA regions previously associated with the disease and 8 regions not previously associated with celiac disease. We identified 5 regions associated with development of tTGA. Two loci associated with celiac disease progression reached a genome-wide association threshold in subjects from Sweden.

Kokoelmat