Staging of Schizophrenia with the Use of PANSS: An International Multi-Center Study
John Waddington; Ludgero Linhares; Antonis T Theofilidis; Maurizio Pompili; Panagiotis Ferentinos; Zsófia Nemes; Elena Dragioti; Henk Temmingh; Michael Berk; Klaudia Domowicz; Janusz Κ Rybakowski; Ioannis Nimatoudis; Xenia Gonda; Xenofon Atmatzidis; Felicia Iftene; Anca-Livia Panfil; Christopher Osunbote; Pavel Knytl; Oluremi Oladele; Pawel Wojciak; Maria Luisa Figueira; Ioannis Michopoulos; Oluyomi Esan; Maija Walta; Loukas Athanasiadis; Henry Karlsson; Filip Spaniel; Alvydas Navickas; Roumen Milev; Nikolaos Smyrnis; Lidija Injac Stevovic; Jan Hilbig; Ida S Haussleiter; Daniil Aptalidis; Sanja Vodopic; Joana Crawford; Konstantinos N Fountoulakis; Siegfried Kasper; Avinash De Sousa; Dusica Lecic-Tosevski; Athanasios Douzenis; Amresh Shrivastava; Cyril Hoschl; Tobias Wikilund; Olivia Dean; Julio Bobes; Rajiv Tandon; Julie Montant; Anita Juhasz; Tiina From; Trayana Hristova; Olivera Vukovic; Erik Thys; Dan Stein; Olga Izmailova; Leonidas Mantonakis; Marc De Hert; Petra Furstova; Fleur Howells; Gamze Erzin; Cristina Bredicean; Anuja Bendre; Dora Vajda; Justine Bouniard; Elmars Rancans; Hasan Karadağ; Valentina Corigliano; Bojana Pejuskovic; Jean-Michel Azorin; Leticia García-Alvarez; Laurynas Bukelskis; Anna Comparelli; Raimo K R Salokangas; Martien Wampers; Anastasia Konsta; Vincent Russell; Daria Smirnova; Luchezar Hranov; Ion Papava; Georg Juckel; Maria Paz Garcia-Portilla
Staging of Schizophrenia with the Use of PANSS: An International Multi-Center Study
Oxford University Press
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825441
https://urn.fi/URN:NBN:fi-fe2021042825441
Tiivistelmä
Introduction: A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.
Methods: Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.
Results: Exploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.
Discussion: This study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.
Methods: Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.
Results: Exploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.
Discussion: This study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.
Kokoelmat
- Rinnakkaistallenteet [19207]