Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors
Lauri Nikkanen; Perttu Permi; Maarit Hellman; Julia Krasensky-Wrzaczek; Brecht Wybouw; Eva-Mari Aro; Esa Tyystjärvi; Sari Järvi; Jaakko Kangasjärvi; Eevi Rintamäki; Fayezeh Aarabi; Helena Tossavainen; Alexey Shapiguzov; Alisdair R Fernie; Michael Wrzaczek; Nina Sipari; Kerri Hunter; Mikael Brosché; Frank Van Breusegem; Markku Keinänen; Saleh Alseekh; Julia P Vainonen; Katrien Van Der Kelen; Bert De Rybel; Arjun Tiwari; Jarkko Salojärvi
Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors
Lauri Nikkanen
Perttu Permi
Maarit Hellman
Julia Krasensky-Wrzaczek
Brecht Wybouw
Eva-Mari Aro
Esa Tyystjärvi
Sari Järvi
Jaakko Kangasjärvi
Eevi Rintamäki
Fayezeh Aarabi
Helena Tossavainen
Alexey Shapiguzov
Alisdair R Fernie
Michael Wrzaczek
Nina Sipari
Kerri Hunter
Mikael Brosché
Frank Van Breusegem
Markku Keinänen
Saleh Alseekh
Julia P Vainonen
Katrien Van Der Kelen
Bert De Rybel
Arjun Tiwari
Jarkko Salojärvi
ELIFE SCIENCES PUBLICATIONS LTD
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825856
https://urn.fi/URN:NBN:fi-fe2021042825856
Tiivistelmä
Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL INDUCED CELL DEATH 1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.
Kokoelmat
- Rinnakkaistallenteet [19207]