1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
Leo-Pekka Lyytikäinen; Olli T. Raitakari; Andre G. Uitterlinden; Cornelia Huth; Daniel Taliun; Harold Snieder; Ilja M. Nolte; Giorgia Girotto; Ulf Gyllensten; Konstantin Strauch; Yongmei Liu; Christa Meisinger; Albert V. Smith; Yasaman Saba; Audrey Y. Chu; Reinhold Schmidt; Daniel I. Chasman; Paolo Gasparini; Holly Kramer; Iris M. Heid; Caroline S. Fox; Murielle Bochud; Kurt Lohman; Stephen J. Hancock; Daniela Ruggiero; Ming-Huei Chen; Mika Kähönen; Thor Aspelund; Vladan Mijatovic; Jingzhong Ding; Daniela Toniolo; Åsa Johansson; Ingrid Borecki; Paul M. Ridker; Reiner Biffar; Oscar H. Franco; Anna Köttgen; Terho Lehtimäki; Melanie Waldenberger; Alexander Teumer; Sylvia Stracke; Albertine J. Oldehinkel; Thomas Meitinger; Abbas Dehghan; Mathias Gorski; Albert Hofman; Fernando Rivadeneira; Nina Hutri-Kähönen; Benedicte Stengel; Bamidele Tayo; Peter J. Van der Most; Bernhard K. Krämer; Georg Homuth; Rodney J. Scott; Giorgio Pistis; Vilmundur Gudnason; Stefan Enroth; Carsten A. Böger; Matthias Olden; Cinzia Sala; Sheila Ulivi; Man Li; Rossella Sorice; Shih-Jen Hwang; Jorma S. Viikari; Karlhans Endlich; Qiong Yang; Douglas Ruderfer; Andres Metspalu; Vincent Chouraki; Catherine Helmer; Helena Schmidt; John Attia; Adrienne Tin; Jean-Charles Lambert; Simon Höllerer; Ruth J. F. Loos; Laura Dengler; Frank B. Hu; Mary F. Feitosa; Marilyn C. Cornelis; Sanaz Sedaghat; Felicia Gomez; Marie Metzger; Gary C. Curhan; Zoltan Kutalik; Massimiliano Cocca; Edith Hofer; Nicole Probst-Hensch; Uwe Völker; Medea Imboden; Josef Coresh; Lenore J. Launer; Christian Gieger; Gerard Tromp; Gerjan Navis; Sylvia E. Rosas; Wolfgang König; Paul Mitchell; Matthias Nauck; Henry Völzke; Marina Ciullo; Adamo Pio d'Adamo; Morris Swertz; Yong Li; Evelin Mihailov; Gudny Eiriksdottir; Peter Vollenweider; Mark A. McEvoy; Martin H. de Borst; Dragana Vuckovic; Tõnu Esko; Peter P. Pramstaller; Christian Pattaro; Ashish Kumar; Eric Boerwinkle; Rainer Rettig; Erwin P. Bottinger; Omri Gottesman; Tamara B. Harris; Elizabeth G. Holliday; Brenda WJH Penninx; Christian Fuchsberger; Yingchang Lu; Jie Jin Wang; Antonietta Robino
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
Leo-Pekka Lyytikäinen
Olli T. Raitakari
Andre G. Uitterlinden
Cornelia Huth
Daniel Taliun
Harold Snieder
Ilja M. Nolte
Giorgia Girotto
Ulf Gyllensten
Konstantin Strauch
Yongmei Liu
Christa Meisinger
Albert V. Smith
Yasaman Saba
Audrey Y. Chu
Reinhold Schmidt
Daniel I. Chasman
Paolo Gasparini
Holly Kramer
Iris M. Heid
Caroline S. Fox
Murielle Bochud
Kurt Lohman
Stephen J. Hancock
Daniela Ruggiero
Ming-Huei Chen
Mika Kähönen
Thor Aspelund
Vladan Mijatovic
Jingzhong Ding
Daniela Toniolo
Åsa Johansson
Ingrid Borecki
Paul M. Ridker
Reiner Biffar
Oscar H. Franco
Anna Köttgen
Terho Lehtimäki
Melanie Waldenberger
Alexander Teumer
Sylvia Stracke
Albertine J. Oldehinkel
Thomas Meitinger
Abbas Dehghan
Mathias Gorski
Albert Hofman
Fernando Rivadeneira
Nina Hutri-Kähönen
Benedicte Stengel
Bamidele Tayo
Peter J. Van der Most
Bernhard K. Krämer
Georg Homuth
Rodney J. Scott
Giorgio Pistis
Vilmundur Gudnason
Stefan Enroth
Carsten A. Böger
Matthias Olden
Cinzia Sala
Sheila Ulivi
Man Li
Rossella Sorice
Shih-Jen Hwang
Jorma S. Viikari
Karlhans Endlich
Qiong Yang
Douglas Ruderfer
Andres Metspalu
Vincent Chouraki
Catherine Helmer
Helena Schmidt
John Attia
Adrienne Tin
Jean-Charles Lambert
Simon Höllerer
Ruth J. F. Loos
Laura Dengler
Frank B. Hu
Mary F. Feitosa
Marilyn C. Cornelis
Sanaz Sedaghat
Felicia Gomez
Marie Metzger
Gary C. Curhan
Zoltan Kutalik
Massimiliano Cocca
Edith Hofer
Nicole Probst-Hensch
Uwe Völker
Medea Imboden
Josef Coresh
Lenore J. Launer
Christian Gieger
Gerard Tromp
Gerjan Navis
Sylvia E. Rosas
Wolfgang König
Paul Mitchell
Matthias Nauck
Henry Völzke
Marina Ciullo
Adamo Pio d'Adamo
Morris Swertz
Yong Li
Evelin Mihailov
Gudny Eiriksdottir
Peter Vollenweider
Mark A. McEvoy
Martin H. de Borst
Dragana Vuckovic
Tõnu Esko
Peter P. Pramstaller
Christian Pattaro
Ashish Kumar
Eric Boerwinkle
Rainer Rettig
Erwin P. Bottinger
Omri Gottesman
Tamara B. Harris
Elizabeth G. Holliday
Brenda WJH Penninx
Christian Fuchsberger
Yingchang Lu
Jie Jin Wang
Antonietta Robino
NATURE PUBLISHING GROUP
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042716817
https://urn.fi/URN:NBN:fi-fe2021042716817
Tiivistelmä
HapMap imputed genome-wide association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 x 10(-8) previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until wholegenome sequencing becomes feasible in large samples.
Kokoelmat
- Rinnakkaistallenteet [19207]