Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Ahluwalia TS; Ameur A; Balkhiyarova Z; Balslev-Harder MN; Bandinelli S; Bartz TM; Baumeister SE; Beilby J; Bentley AR; Berry D; Bielak LF; Bis JC; Blangero J; Boehnke M; Boomsma DI; Bouchard C; Brage S; Braund PS; Brody JA; Broos S; Bruinenberg M; Chasman DI; Chong M; Chu AY; Cole JW; Collins FS; Cornelis MC; Cupples LA; De Geus EJC; Deldicque L; Den Hoed M; Dorajoo R; Dorr M; Dueker ND; Ekelund U; Emmerich A; Enroth S; Esko T; Evans MK; Faul JD; Feenstra B; Feitosa MF; Fernandez-Rhodes L; Ferrucci L; Fohner AE; Fornage M; Fox C; Franco OH; Galesloot TE; Garland T; Gieger C; Gordon SD; Graff M; Grarup N; Gudnason V; Gyllensten U; Hall LM; Haller T; Hansen T; Hartman CA; Hartwig FP; Hayward C; Heard-Costa N; Heiss G; Hemerich D; Hevener AL; Hillis DA; Holzapfel C; Horta BL; Hui J; Huikari V; Hypponen E; Illig T; Jackson AU; Jago R; James A; Jarvelin MR; Johansson A; Johnson WC; Jorgensen AM; Joshi PK; Jung T; Kaakinen MA; Kahonen M; Kardia SLR; Karlsson R; Kasbohm E; Kerr KF; Kiemeney LA; Kilpelainen TO; Kim B; Koh WP; Kolcic I; Koolhaas CM; Kraft PP; Krook A; Kutalik Z; Kuusisto J; Laakso M; Lagou V; Langenberg C; Launer LJ; Le Marchand L; Lehtimaki T; Li AH; Lind PA; Linneberg A; Liu CT; Loos RJF; Lorentzon M; Luan JA; Lyytikainen LP; Magnusson PKE; Mangino M; Martin NG; Mazzaferro E; Medland SE; Melbye M; Metspalu A; Metzendorf C; Meyre D; Milaneschi Y; Monroe KR; Moore T; Moscati A; Musk B; Nelson CP; Nolte IM; North KE; Ohlsson C; Oldehinkel AJ; Orho-Melander M; Pacolet A; Pare G; Park T; Pedersen NL; Pedersen O; Penninx BWJH; Pers TH; Perusse L; Peters A; Peyser PA; Pillon NJ; Polasek O; Pool R; Power C; Prokopenko I; Raitakari OT; Reedik M; Reiner AP; Richmond RC; Ridker PM; Rivera NV; Robiou-Du-Pont S; Rotimi CN; Rudan I; Ryan K; Samani NJ; Sarzynski MA; Schraut KE; Schulz CA; Scott LJ; Scott RA; Sidney S; Siggeirsdottir K; Sim X; Smith AV; Smith GD; Smith JA; Snieder H; Sonestedt E; Sorensen TIA; Spector TD; Stringham HM; Strom M; Tai ES; Tanaka T; Teo KK; Teumer A; Thomis MAI; Thorand B; Timpson NJ; Tonjes A; Tremblay A; Turman C; Uitterlinden AG; Van Dam RM; Van Duijn CM; Van Rooij FJA; Van Schoor N; Van Vliet-Ostaptchouk JV; Van der Most PJ; Van der Velde N; Vangipurapu J; Vanmunster M; Vidal PM; Volker U; Vollenweider P; Volzke H; Voortman T; Waeber G; Wang Z; Wareham NJ; Weir DR; Wichmann HE; Willemsen G; Williams K; Wilson JF; Wong Q; Xu HC; Young KL; Yuan JM; Zhang XS; Zhao JH; Zhao W; Zierath JR; Zillikens MC; Zonderman AB
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Ahluwalia TS
Ameur A
Balkhiyarova Z
Balslev-Harder MN
Bandinelli S
Bartz TM
Baumeister SE
Beilby J
Bentley AR
Berry D
Bielak LF
Bis JC
Blangero J
Boehnke M
Boomsma DI
Bouchard C
Brage S
Braund PS
Brody JA
Broos S
Bruinenberg M
Chasman DI
Chong M
Chu AY
Cole JW
Collins FS
Cornelis MC
Cupples LA
De Geus EJC
Deldicque L
Den Hoed M
Dorajoo R
Dorr M
Dueker ND
Ekelund U
Emmerich A
Enroth S
Esko T
Evans MK
Faul JD
Feenstra B
Feitosa MF
Fernandez-Rhodes L
Ferrucci L
Fohner AE
Fornage M
Fox C
Franco OH
Galesloot TE
Garland T
Gieger C
Gordon SD
Graff M
Grarup N
Gudnason V
Gyllensten U
Hall LM
Haller T
Hansen T
Hartman CA
Hartwig FP
Hayward C
Heard-Costa N
Heiss G
Hemerich D
Hevener AL
Hillis DA
Holzapfel C
Horta BL
Hui J
Huikari V
Hypponen E
Illig T
Jackson AU
Jago R
James A
Jarvelin MR
Johansson A
Johnson WC
Jorgensen AM
Joshi PK
Jung T
Kaakinen MA
Kahonen M
Kardia SLR
Karlsson R
Kasbohm E
Kerr KF
Kiemeney LA
Kilpelainen TO
Kim B
Koh WP
Kolcic I
Koolhaas CM
Kraft PP
Krook A
Kutalik Z
Kuusisto J
Laakso M
Lagou V
Langenberg C
Launer LJ
Le Marchand L
Lehtimaki T
Li AH
Lind PA
Linneberg A
Liu CT
Loos RJF
Lorentzon M
Luan JA
Lyytikainen LP
Magnusson PKE
Mangino M
Martin NG
Mazzaferro E
Medland SE
Melbye M
Metspalu A
Metzendorf C
Meyre D
Milaneschi Y
Monroe KR
Moore T
Moscati A
Musk B
Nelson CP
Nolte IM
North KE
Ohlsson C
Oldehinkel AJ
Orho-Melander M
Pacolet A
Pare G
Park T
Pedersen NL
Pedersen O
Penninx BWJH
Pers TH
Perusse L
Peters A
Peyser PA
Pillon NJ
Polasek O
Pool R
Power C
Prokopenko I
Raitakari OT
Reedik M
Reiner AP
Richmond RC
Ridker PM
Rivera NV
Robiou-Du-Pont S
Rotimi CN
Rudan I
Ryan K
Samani NJ
Sarzynski MA
Schraut KE
Schulz CA
Scott LJ
Scott RA
Sidney S
Siggeirsdottir K
Sim X
Smith AV
Smith GD
Smith JA
Snieder H
Sonestedt E
Sorensen TIA
Spector TD
Stringham HM
Strom M
Tai ES
Tanaka T
Teo KK
Teumer A
Thomis MAI
Thorand B
Timpson NJ
Tonjes A
Tremblay A
Turman C
Uitterlinden AG
Van Dam RM
Van Duijn CM
Van Rooij FJA
Van Schoor N
Van Vliet-Ostaptchouk JV
Van der Most PJ
Van der Velde N
Vangipurapu J
Vanmunster M
Vidal PM
Volker U
Vollenweider P
Volzke H
Voortman T
Waeber G
Wang Z
Wareham NJ
Weir DR
Wichmann HE
Willemsen G
Williams K
Wilson JF
Wong Q
Xu HC
Young KL
Yuan JM
Zhang XS
Zhao JH
Zhao W
Zierath JR
Zillikens MC
Zonderman AB
NATURE PORTFOLIO
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022110164017
https://urn.fi/URN:NBN:fi-fe2022110164017
Tiivistelmä
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.
Kokoelmat
- Rinnakkaistallenteet [19207]