Effect of respiratory motion correction and CT-based attenuation correction on dual-gated cardiac PET image quality and quantification
Schultz, Jussi (2022-02-03)
Effect of respiratory motion correction and CT-based attenuation correction on dual-gated cardiac PET image quality and quantification
Schultz, Jussi
(03.02.2022)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
suljettu
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022020417789
https://urn.fi/URN:NBN:fi-fe2022020417789
Tiivistelmä
Dual-gating reduces respiratory and cardiac motion effects but increases noise. With motion correction, motion is minimized and image quality preserved. We applied motion correction to create end-diastolic respiratory motion corrected images from dual-gated images.
[18F]-fluorodeoxyglucose ([18F]-FDG) PET images of 13 subjects were reconstructed with 4 methods: non-gated, dual-gated, motion corrected, and motion corrected with 4D-CT (MoCo-4D). Image quality was evaluated using standardized uptake values, contrast ratio, signal-to-noise ratio, coefficient of variation, and contrast-to-noise ratio. Motion minimization was evaluated using myocardial wall thickness.
MoCo-4D showed improvement for contrast ratio (2.83 vs. 2.76), signal-to-noise ratio (27.5 vs. 20.3) and contrast-to-noise ratio (14.5 vs. 11.1) compared to dual-gating. The uptake difference between MoCo-4D and non-gated images was non-significant (P > 0.05) for the myocardium (2.06 vs. 2.15 g/mL), but significant (P < 0.05) for the blood pool (0.80 vs. 0.86 g/mL). Non-gated images had the lowest coefficient of variation (27.3%), with significant increase for all other methods (31.6-32.5%). MoCo-4D showed smallest myocardial wall thickness (16.6 mm) with significant decrease compared to non-gated images (20.9 mm).
End-diastolic respiratory motion correction and 4D-CT resulted in improved motion minimization and image quality over standard dual-gating.
[18F]-fluorodeoxyglucose ([18F]-FDG) PET images of 13 subjects were reconstructed with 4 methods: non-gated, dual-gated, motion corrected, and motion corrected with 4D-CT (MoCo-4D). Image quality was evaluated using standardized uptake values, contrast ratio, signal-to-noise ratio, coefficient of variation, and contrast-to-noise ratio. Motion minimization was evaluated using myocardial wall thickness.
MoCo-4D showed improvement for contrast ratio (2.83 vs. 2.76), signal-to-noise ratio (27.5 vs. 20.3) and contrast-to-noise ratio (14.5 vs. 11.1) compared to dual-gating. The uptake difference between MoCo-4D and non-gated images was non-significant (P > 0.05) for the myocardium (2.06 vs. 2.15 g/mL), but significant (P < 0.05) for the blood pool (0.80 vs. 0.86 g/mL). Non-gated images had the lowest coefficient of variation (27.3%), with significant increase for all other methods (31.6-32.5%). MoCo-4D showed smallest myocardial wall thickness (16.6 mm) with significant decrease compared to non-gated images (20.9 mm).
End-diastolic respiratory motion correction and 4D-CT resulted in improved motion minimization and image quality over standard dual-gating.