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Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
Mutations in numerous genes contribute to human cancer, with different oncogenic lesions prevalent in different cancer types. However, the malignant phenotype is simple, characterized by unrestricted cell growth, invasion, ... -
Metabolomic Alterations in Patients with Obesity and the Impact of Metabolic Bariatric Surgery: Insights for Future Research
Metabolomics has emerged as a vital tool for understanding the body's responses to therapeutic interventions. Metabolic bariatric surgery (MBS) is widely recognized as the most effective treatment modality for severe obesity ... -
”Tytöt saavat olla tyttöjä ja pojat poikia” – Sukupuoli perussuomalaisten puolueohjelmissa
<p>Artikkelissa tarkastellaan laadullisen sisällönanalyysin ja määrällisen sisällönerittelyn avulla sukupuolen saamia merkityksiä perussuomalaisten puolueohjelmissa (n = 52). Merkityksiä analysoidaan kolmessa ajanjaksossa ... -
HDAC1 is involved in the destabilization of the HSF2 protein under nonstress and stress conditions
Heat shock transcription factors 1 and 2 (HSF1 and HSF2) are the major regulators of the cellular response to stressors, notably to heat shock and to oxidative stress. HSF1 and HSF2 are also important contributors in ... -
‘How would you define your sexuality?’ analyzing the questions asked in official asylum interviews with sexual minorities
<p> Asylum applications lodged by sexual minorities are expected to continue increasing in the future. Asylum interviews should be conducted in a way that supports fair and accurate asylum decision-making. Yet, psychological ... -
Appendicolith classification: physical and chemical properties of appendicoliths in patients with CT diagnosed acute appendicitis - a prospective cohort study
<p><strong>Objective</strong> Appendicoliths are associated with a more complicated course of acute appendicitis and failure of non-operative treatment. We aimed to update the appendicolith classification originally described ... -
Uuden syöpälääkkeen hyväksymisprosessi ja käyttöönotto
Uuden syöpälääkkeen hyväksymis- ja käyttöönottoprosessi Suomessa on monivaiheinen ja sisältää useita arviointivaiheita, ennen kuin lääke tulee potilaiden käyttöön. Uusilta lääkkeiltä edellytetään vaikuttavuutta, turvallisuutta ... -
Prophylactic Retrorectus Mesh Versus Small-Stitch Closure After Emergency Midline Laparotomy: 2-Year Results of a Randomized Controlled Trial
<p><strong>Introduction: </strong></p><p>Incisional hernias (IH) are common complications following emergency midline laparotomies. Mesh reinforcement has shown efficacy in preventing incisional hernias in elective surgeries, ... -
Kriittinen oikeustutkimus tarvitsee monialaisuutta
<p>Oikeutta voidaan lähestyä monesta eri näkökulmasta. Laki ja lainkäyttö ovat vallankäyttöä, mutta yleisempi yhteiskunnallinen vallankäyttö on myös oikeudellinen ilmiö. Tällöin oikeutta, lakia ja sen käyttöä yhteiskunnan ... -
Kouluorganisaatioiden turvallisuuskulttuuri omatoimisen varautumisen arvioinnin perusteella : Monitapaustutkimus perusopetuksen kouluissa
<p> <strong>The safety culture of a school organization based on evaluation of self-preparedness – a multi-case study in comprehensive education schools</strong><br></p><p>School safety is a legal right for every learner ... -
Life-course Factors and Later Life Health in Eastern and Western Europe
<p>Human development and ageing are lifelong processes, where earlier life conditions and events are interlinked with later life outcomes. Patterns of inequality within and among cohorts emerge over time as products of the ... -
Structural approach to language revitalisation: revival of Aanaar Saami
Arctic Encounters<p>Aanaar Saami is an indigenous language spoken by an estimated 400 people mainly around Lake Aanaar in Northern Finland. Within the past three decades, the once critically endangered language has acquired dozens of new ... -
The lower limit of reactivity as a potential individualised cerebral perfusion pressure target in traumatic brain injury: a CENTER-TBI high-resolution sub-study analysis
<p><strong>Background: </strong>A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below the individual lower limit of reactivity (LLR) is ... -
Covalently Palladated Oligonucleotides Through Oxidative Addition of Pd-0
An 11-mer oligonucleotide incorporating a central (2-iodobenzoylamino)methyl residue has been synthesized and palladated by oxidative addition of Pd-2(dba)(3). UV melting profiles of the duplexes formed by the palladated ... -
Height and nigral neuron density in Parkinson's disease
<p><strong>Background: </strong>The dopaminergic system modulates growth hormone secretion and previous results have suggested a link between short stature and an increased risk of Parkinson's disease (PD).</p><p><strong ... -
Device-Measured Sleep Characteristics, Daily Step Count, and Cardiometabolic Health Markers: Findings From the Prospective Physical Activity, Sitting, and Sleep (ProPASS) Consortium
<p><b>BACKGROUND:</b><br></p><p> Sleep and physical activity (PA) are important lifestyle-related behaviors that impact cardiometabolic health. This study investigated the joint associations of daily step count and sleep ... -
Gone with the Wind: JWST-MIRI Unveils a Strong Outflow from the Quiescent Stellar-mass Black Hole A0620-00
<p>We present new observations of the black hole X-ray binary A0620-00 using the Mid-Infrared (MIR) Instrument on the James Webb Space Telescope, during a state where the X-ray luminosity is 9 orders of magnitude below ... -
Tuning the Legacy Survey of Space and Time Observing Strategy for Solar System Science: Incremental Templates in Year 1
The Vera C. Rubin Observatory is due to commence the 10 yr Legacy Survey of Space and Time (LSST) at the end of 2025. To detect transient/variable sources and identify solar system objects (SSOs), the processing pipelines ... -
Yksilön sopeuttajia vai yhteiskunnan muuttajia? Tuloksellisuusarviointi vammaisjärjestöjen ja vammaisten ihmisten välisen suhteen määrittäjänä
<div>Raportointivelvollisuus ja tuloksellisuusarviointi ovat tulleet kiinteäksi osaksi kansalaisjärjestöjen jokapäiväistä toimintaa viime vuosikymmeninä. Artikkelissa tarkastellaan tuloksellisuusarviointia vammaisjärjestöjen ... -
Leveraging active learning-enhanced machine-learned interatomic potential for efficient infrared spectra prediction
<p>Infrared (IR) spectroscopy is a pivotal analytical tool as it provides real-time molecular insight into material structures and enables the observation of reaction intermediates in situ. However, interpreting IR spectra ...
