Cerebral small vessel disease genomics and its implications across the lifespan
Sigurdur Sigurdsson; Marie-Gabrielle Duperron; Erik B. van den Akker; Russell J. Thomson; Alexander Teumer; David S. Knopman; Jiyang Jiang; Henry Brodaty; Sabrina Schilling; Sudha Seshadri; Perminder S. Sachdev; Philip L. De Jager; Aniket Mishra; Albert V. Smith; Robin Bülow; Evangelos Evangelou; Yoichiro Kamatani; Joshua C. Bis; Mohamad Habes; David A. Bennett; Neelum T. Aggarwal; Katharina Wittfeld; Eric Boerwinkle; Stephen Sidney; Nicola J. Armstrong; Aicha Soumaré; Ami Tsuchida; R. Nick Bryan; Pamela J. Schreiner; Gail Davies; Natalie Terzikhan; Stéphanie Debette; Karen A. Mather; Mohammad A. Ikram; Saori Sakaue; Rebecca F. Gottesman; Mark A. van Buchem; Rebekah E. McWhirter; Sharon L. R. Kardia; Maria C. Valdés Hernández; Muralidharan Sargurupremraj; Helen R. Warren; Tavia E. Evans; William T. Longstreth Jr; Yasaman Saba; Gudny Eiriksdottir; Margaret J. Wright; Quentin Le Grand; Alexa S. Beiser; Xueqiu Jian; Reinhold Schmidt; Laurent Petit; Jerome I. Rotter; Cornelia M. Van Duijn; Anbupalam Thalamuthu; Christophe Tzourio; Wiro J. Niessen; Kazuya Setoh; Meike W. Vernooij; Stella Trompet; Kazumichi Yoshida; Mark Lathrop; Peter R. Schofield; Julian Trollor; David-Alexandre Trégouët; Saskia P. Hagenaars; Laure Zago; Maria J. Knol; Uwe Völker; Constance Bordes; Josée Dupuis; Edith Hofer; Cora E. Lewis; Lisa R. Yanek; Bruce M. Psaty; Thomas H. Mosley; Gregory Beaudet; Claudia L. Satizabal; Denis A. Evans; Helena Schmidt; Hans J. Grabe; Philippe Amouyel; Paul M. Matthews; International Headache Genomics Consortium (IHGC); International Network against Thrombosis (INVENT) Consortium; Rajan B. Kumar; Chloé Sarnowski; Charles DeCarli; J. Wouter Jukema; Joanna M. Wardlaw; Velandai K. Srikanth; David J. Stott; Mark E. Bastin; Yukinori Okada; Yasuharu Tabara; Myriam Fornage; Susana Muñoz Maniega; Susumu Miyamoto; Marian Beekman; Wei Wen; Hieab H. Adams; Marcus Dörr; Vilmundur Gudnason; Stephen T. Turner; Paul A. Nyquist; Manabu Nagata; Bernard Mazoyer; Oscar L. Lopez; Jennifer A. Smith; David Ames; Jeroen van der Grond; Ian J. Deary; Lenore J. Launer; Fumihiko Matsuda; Wei Zhao; Eline P. Slagboom; John B. Kwok; Hideaki Suzuki
https://urn.fi/URN:NBN:fi-fe2021042824324
Tiivistelmä
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials.
Kokoelmat
- Rinnakkaistallenteet [19207]
Samankaltainen aineisto
Näytetään aineisto, joilla on samankaltaisia nimekkeitä, tekijöitä tai asiasanoja.
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Shared heritability and functional enrichment across six solid cancers
Kim De Ruyck; Zsofia Kote-Jarai; Ruth C. Travis; Alfons Meindl; Miranda Pring; Anna Marie Mulligan; Karina Dalsgaard Sorensen; Trinidad Caldés; Stephanie Weinstein; D. Gareth Evans; Heinz-Josef Lenz; Marcia Cruz Correa; Sonja I. Berndt; Manolis Kogevinas; Flavio Lejbkowicz; Anna deFazio; Jenny Lester; Melinda C. Aldrich; M. Dawn Teare; Jonathan P. Tyrer; Kari Stefansson; Henrik Gronberg; Mark N. Brook; James D. Brenton; Kristin K. Zorn; Kenneth Muir; Robert L. Nussbaum; Adam S. Kibel; Austin Miller; Fergus J. Couch; Patricia A. Ganz; Jacques Simard; Wei Zheng; Gabriella Cadoni; Andrew F. Olshan; Michael Woods; Jeri Kim; Annika Lindblom; Marc T. Goodman; Thilo Dörk; Barbara Burwinkel; Robert Winqvist; Ulrike Peters; Carl Blomqvist; Hongbing Shen; Jeroen R. Huyghe; Lisa Cannon-Albright; Carolina Ellberg; Christopher A. Haiman; Rayjean J. Hung; Paolo Radice; Ana Vega; Christopher K. Edlund; Shelley S. Tworoger; Kathryn L. Penney; Hiltrud Brauch; Susanne M. Arnold; Drakoulis Yannoukakos; Mia M. Gaudet; Peter A. Fasching; Jenny L. Donovan; Rosa B. Barkardottir; Peter Hillemanns; Bogdan Pasaniuc; Heike Bickeböller; Digna R Velez Edwards; Karin Sundfeldt; Claudine Isaacs; Mark S. Goldberg; Manjeet K. Bolla; Darya Prokofyeva; Triantafillos Liloglou; Anna Jakubowska; Martha L. Slattery; Harvey A. Risch; Jan Lubiński; Eunjung Lee; Catherine M. Phelan; Mary Anne Rossing; Kay-Tee Khaw; Li Li; Roger L. Milne; Marc Tischkowitz; Stephanie L. Schmit; Orland Diez; Daniel D. Buchanan; Antonis C. Antoniou; Sue Ann Ingles; Kenneth Offit; José A. García-Sáenz; Joe Dennis; Brenda Diergaarde; Kristan J. Aronson; Edith Olah; Christopher I. Li; Karoline B. Kuchenbaecker; Robert L. Ferris; Lorelei Mucci; Nhu D. Le; Maria A. Caligo; David V. Conti; Davor Lessel; Paul D. P. Pharoah; Jong Y. Park; Andrew R. Ness; Gregory Idos; Jolanta Kupryjanczyk; Liene Nikitina-Zake; Jacek Gronwald; Maria Teresa Landi; Kjell Grankvist; Beth Y. Karlan; Aage Haugen; Vessela N. Kristensen; Sebastian Stintzing; Elisa V. Bandera; Stephen N. Thibodeau; Cornelia M. Ulrich; Fredrick R. Schumacher; Linda E. Kelemen; Emily White; Janet L. Stanford; Stella Koutros; Peter J. Hulick; Hans Brunnström; Lambertus A. Kiemeney; Victor Moreno; Corina Lesseur; Els Van Nieuwenhuysen; Taymaa May; Geoffrey Liu; Miguel Elías Aguado-Barrera; Graham G. Giles; Chu Chen; Cezary Cybulski; Jane C. Figueiredo; Dijana Plaseska-Karanfilska; Emmanouil Saloustros; Richa Saxena; Celine M. Vachon; Judy Garber; Richard Houlston; Penella Woll; Amanda B. Spurdle; Ute Hamann; David C. Christiani; Heli Nevanlinna; Niclas Håkansson; Eric J. Duell; David E. Goldgar; Ralf Butzow; John L. Hopper; Pascal Guénel; Johanna Schleutker; Robert J. MacInnis; Fredrik Wiklund; Peter Devilee; Younghun Han; Kirsten B. Moysich; Matthias W. Beckmann; Elinor J. Sawyer; Jochen Hampe; Hermann Brenner; Julia A. Knight; Victoria L. Stevens; Stephanie A. Bien; Hilary K. Finucane; Jyotsna Batra; Marjorie J. Riggan; Nawaid Usmani; Natalia V. Bogdanova; Catharine M. L. West; Kathleen B. M. Claes; Anthony J. Swerdlow; Ian Campbell; Mark H. Greene; Paul A. Townsend; Amanda I. Phipps; Peter Kraft; Xia Jiang; Michael T. Parsons; Duncan Thomas; Ali Amin Al Olama; Angela Cox; Loic Le Marchand; Miriam Dwek; Sara Margolin; Peter T. Campbell; Amanda E. Toland; Natalia N. Antonenkova; Hoda Anton-Culver; Kathryn L. Terry; Xifeng Wu; Judith Clements; Anna H. Wu; André L. Carvalho; Line Bjørge; Alice S. Whittemore; Penelope M. Webb; Susanne K. Kjaer; Irene L. Andrulis; Montserrat García-Closas; Douglas A. Levine; Olufunmilayo I. Olopade; Noralane M. Lindor; Michael Hoffmeister; Gary Goodman; V. Wendy Setiawan; Daniele Campa; Clarice R. Weinberg; Andrew K. Godwin; Alkes L. Price; Estrid Høgdall; Javier Benitez; David G. Huntsman; Katherine L. Nathanson; Stephen B. Gruber; Mikael Johansson; Tanja Pejovic; Wilbert H M. Peters; Mary Beth Terry; Rebecca Sutphen; Banu K. Arun; Mark A. Jenkins; Lesley McGuffog; Håkan Olsson; Goska Leslie; Andrew Berchuck; Francesmary Modugno; Frank Claessens; Douglas F. Easton; Philip Lazarus; Manuela Gago-Dominguez; Pooja Middha; Diether Lambrechts; Matthew B. Schabath; Lisa F. Newcomb; Evgeny N. Imyanitov; Daniel R. Barnes; Dale P. Sandler; Demetrius Albanes; Christian F. Singer; Nora Pashayan; Paul James; Alicja Wolk; Rosalind A. Eeles; Gad Rennert; Stephan Lam; Florian Heitz; Weiva Sieh; Joan Brunet; David E. Neal; H-Erich Wichmann; Kamila Czene; Freddie C. Hamdy; Nadine Tung; Barry S. Rosenstein; Melissa C. Southey; Shanbeh Zienolddiny; Fotios Loupakis; Monique J. Roobol; Angela Risch; Arto Mannermaa; Neil Caporaso; Kyriaki Michailidou; Olivia Fletcher; Sara Lindström; Graham Casey; Christiane Maier; Mary B. Daly; Stefania Boccia; Hedy S. Rennert; Tabea Kühl; Marjanka K. Schmidt; Georgia Chenevix-Trench; Martin Lacko; J. Margriet Collée; Radka Kaneva; Catherine M. Tangen; David J. Hunter; Lovise Maehle; Andrew T. Chan; Adonina Tardon; Simon A. Gayther; Jeffrey N. Weitzel; Argyrios Ziogas; Géraldine Cancel-Tassin; Elizabeth J. van Rensburg; James McKay; Diana Torres; Li Hsu; Susan L. Neuhausen; Jack A. Taylor; Finn Cilius Nielsen; Eitan Friedman; Diana M. Eccles; Per Hall; Marco Montagna; Ellen L. Goode; Julie M. Cunningham; Amit D. Joshi; Erin M. Siegel; Renée T. Fortner; Jenny Chang-Claude; Steven J. Gallinger; Jennifer Stone; Esther M. John; Elza Khusnutdinova; Ana Osorio; Stephen J. Chanock; Rolando Herrero; Stig E. Bojesen; Alison M. Dunning; Leon Raskin; Robert J. Hamilton; Qin Wang; Christopher I. Amos; Polly A. Newcomb; Mark C. Weissler; Manuel R. Teixeira; Yun-Chul Hong; Paul J. Brennan; Mattias Johansson; Børge G. Nordestgaard; Mads Thomassen; Florentia Fostira; Sara Benlloch; Eloiza H. Tajara; Jacqueline M. Lane; Silvia Franceschi; Susan J. Ramus; Hardev Pandha; Angeline S. AndrewQuantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total ... -
Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry
Niederseer David; Karakas Mahir; D’Ascenzo Fabrizio; Levinson Rena A.; Templin Christian; Kobza Richard; Szawan Konrad A.; Carrilho-Ferreira Pedro; Akin Ibrahim; Galiuto Leonarda; Sarcon Annahita; Bossone Eduardo; Schönberger Maximilian; Tousek Petr; Saito Shigeru; Jansen Thomas; Dichtl Wolfgang; Murakami Tsutomu; Shiomura Reiko; Shimizu Wataru; Burgdorf Christof; Seifert Burkhardt; Jacobshagen Claudius; MacCarthy Philip; Crea Filippo; Liu Kan; Cammann Victoria L.; Paolini Carla; Prasad Abhiram; Gilyarov Mikhail; Shilova Alexandra; Banning Adrian; Jaguszewski Milosz; Nakamura Shunichi; Pott Alexander; Ishibashi Iwao; Rajan Lawrence; Cuneo Alessandro; Delmas Clément; Knorr Maike; Napp L. Christian; Bax Jeroen J.; Empen Klaus; Schunkert Heribert; Mizuno Shingo; Borggrefe Martin; Heiner Susanne; Bauersachs Johann; Felix Stephan B.; Widimský Petr; Kozel Martin; Bridgman Paul; Di Vece Davide; Opolski Grzegorz; El-Battrawy Ibrahim; Wakita Masaki; Jörg Lucas; Fischer Thomas A.; Rickli Hans; Lüscher Thomas F.; Maier Lars S.; Bianco Matteo; Airaksinen K. E. Juhani; Di Mario Carlo; Gili Sebastiano; Osswald Stefan; Lairez Olivier; Meyer Philippe; Bilato Claudio; Poglajen Gregor; Franke Jennifer; Kimura Akihisa; Beug Daniel; Kaiser Christoph; Katus Hugo A.; Galuszka Jan; Isogai Toshiaki; Tschöpe Carsten; Winchester David E.; Suzuki Noriko; Noutsias Michel; Hauck Christian; Koenig Wolfgang; Said Samir M.; Vasankari Tuija; Dworakowski Rafal; Rihal Charanjit S.; Kobayashi Yoshio; Dreiding Sara; Shinbane Jerold; Himi Toshiharu; Hasenfuß Gerd; Yamaguchi Tetsuo; Pieske Burkert M.; Pinto Fausto J.; Würdinger Michael; Wischnewsky Manfred; Citro Rodolfo; Imori Yoichi; Böhm Michael; Gilyarova Ekaterina; Michels Guido; Budnik Monika; Ukena Christian; Braun-Dullaeus Ruediger C.; Horowitz John D.; Thiele Holger; Neuhaus Michael; Chan Christina; Cuculi Florim; Kherad Behrouz; Ikari Yuji; Petkova Vanya; Ruschitzka Frank; Mochizuki Hiroki; Münzel Thomas; Tomita Yasuhiro; Rottbauer Wolfgang; Pfister Roman; Arroja Jose David; Ghadri Jelena R.; Takano Hitoshi; Sorici-Barb Ioana; Kato Ken<p>Background <br></p><p>Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics ... -
Polarimetric Properties of Event Horizon Telescope Targets from ALMA
Akiyama Kazunori; Alberdi Antxon; Alef Walter; Algaba Juan Carlos; Anantua Richard; Asada Keiichi; Azulay Rebecca; Baczko Anne-Kathrin; Ball David; Baloković Mislav; Barrett John; Benson Bradford A.; Bintley Dan; Blackburn Lindy; Blundell Raymond; Boland Wilfred; Bouman Katherine L.; Bower Geoffrey C.; Boyce Hope; Bremer Michael; Brinkerink Christiaan D.; Brissenden Roger; Britzen Silke; Broderick Avery E.; Broguiere Dominique; Bronzwaer Thomas; Bruni Gabriele; Byun Do-Young; Carlstrom John E.; Chael Andrew; Chan Chi-kwan; Chatterjee Koushik; Chatterjee Shami; Chen Ming-Tang; Chen Yongjun; Chesler Paul M.; Cho Ilje; Christian Pierre; Conway John E.; Cordes James M.; Crawford Thomas M.; Crew Geoffrey B.; Cruz-Osorio Alejandro; Cui Yuzhu; Davelaar Jordy; De Laurentis Mariafelicia; Deane Roger; Dempsey Jessica; Desvignes Gregory; Dexter Jason; Doeleman Sheperd S.; Eatough Ralph P.; Falcke Heino; Farah Joseph; Fish Vincent L.; Fomalont Ed; Ford H. Alyson; Fraga-Encinas Raquel; Freeman William T.; Friberg Per; Fromm Christian M.; Fuentes Antonio; Galison Peter; Gammie Charles F.; García Roberto; Gentaz Olivier; Georgiev Boris; Goddi Ciriaco; Gold Roman; Gopakumar A.; Gu Minfeng; Gurwell Mark; Gómez José L.; Gómez-Ruiz Arturo I.; Hada Kazuhiro; Haggard Daryl; Hecht Michael H.; Hernández-Gómez Antonio; Herrero-Illana Ruben; Hesper Ronald; Ho Luis C.; Ho Paul; Honma Mareki; Huang Chih-Wei L.; Huang Lei; Hughes David H.; Impellizzeri C. M. Violette; Ingram Adam; Inoue Makoto; Issaoun Sara; James David J.; Jannuzi Buell T.; Janssen Michael; Jeter Britton; Jiang Wu; Jimenez-Rosales Alejandra; Johnson Michael D.; Jorstad Svetlana; Jung Taehyun; Kadler Matthias; Karami Mansour; Karuppusamy Ramesh; Kawashima Tomohisa; Keating Garrett K.; Kettenis Mark; Kim Dong-Jin; Kim Jae-Young; Kim Jongsoo; Kim Junhan; Kino Motoki; Koay Jun Yi; Koch Patrick M.; Kofuji Yutaro; Komossa S.; Kovalev Y. Y.; Koyama Shoko; Kramer Carsten; Kramer Michael; Krichbaum Thomas P.; Kuo Cheng-Yu; Lauer Tod R.; Lee Sang-Sung; Levis Aviad; Li Yan-Rong; Li Zhiyuan; Lico Rocco; Lindahl Greg; Lindqvist Michael; Liu Jun; Liu Kuo; Liuzzo Elisabetta; Lo Wen-Ping; Lobanov Andrei P.; Loinard Laurent; Lonsdale Colin; Lu Ru-Sen; MacDonald Nicholas R.; Mao Jirong; Marchili Nicola; Markoff Sera; Marrone Daniel P.; Marscher Alan P.; Martí-Vidal Iván; Matsushita Satoki; Matthews Lynn D.; Medeiros Lia; Mejías Alejandro Mus; Menten Karl M.; Messias Hugo; Mizuno Izumi; Mizuno Yosuke; Moran James M.; Moriyama Kotaro; Moscibrodzka Monika; Muders Dirk; Musoke Gibwa; Müller Cornelia; Nagai Hiroshi; Nagar Neil M.; Nakamura Masanori; Narayan Ramesh; Narayanan Gopal; Natarajan Iniyan; Nathanail Antonios; Neilsen Joey; Neri Roberto; Ni Chunchong; Noutsos Aristeidis; Nowak Michael A.; Okino Hiroki; Olivares Héctor; Ortiz-León Gisela N.; Oyama Tomoaki; Palumbo Daniel C. M.; Park Jongho; Patel Nimesh; Pen Ue-Li; Perucho Manel; Pesce Dominic W.; Piétu Vincent; Plambeck Richard; PopStefanija Aleksandar; Porth Oliver; Prather Ben; Preciado-López Jorge A.; Psaltis Dimitrios; Pu Hung-Yi; Pötzl Felix M.; Ramakrishnan Venkatessh; Rao Ramprasad; Rawlings Mark G.; Raymond Alexander W.; Rezzolla Luciano; Ricarte Angelo; Ripperda Bart; Roelofs Freek; Rogers Alan; Ros Eduardo; Rose Mel; Roshanineshat Arash; Rottmann Helge; Roy Alan L.; Ruszczyk Chet; Rygl Kazi L. J.; Rösch Florian; Sasada Mahito; Savolainen Tuomas; Schloerb F. Peter; Schuster Karl-Friedrich; Shao Lijing; Shen Zhiqiang; Small Des; Sohn Bong Won; SooHoo Jason; Sun He; Sánchez Salvador; Sánchez-Arguelles David; Tazaki Fumie; Tetarenko Alexandra J.; Tiede Paul; Tilanus Remo P. J.; Titus Michael; Toma Kenji; Torne Pablo; Traianou Efthalia; Trent Tyler; Trippe Sascha; Valtonen Mauri; Wagner Jan; Ward-Thompson Derek; Wardle John; Weintroub Jonathan; Wex Norbert; Wharton Robert; Wielgus Maciek; Wong George N.; Wu Qingwen; Yoon Doosoo; Young André; Young Ken; Younsi Ziri; Yuan Feng; Yuan Ye-Fei; Zensus J. Anton; Zhao Guang-Yao; Zhao Shan-Shan; van Bemmel Ilse; van Langevelde Huib Jan; van Rossum Daniel R.; Özel Feryal<p>We present the results from a full polarization study carried out with the Atacama Large Millimeter/submillimeter Array (ALMA) during the first Very Long Baseline Interferometry (VLBI) campaign, which was conducted in ...