Breast milk immune mediators
Viitaharju, Jenni (2025-01-24)
Breast milk immune mediators
(24.01.2025)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
suljettu
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe202502038937
https://urn.fi/URN:NBN:fi-fe202502038937
Tiivistelmä
Breast milk provides optimal nutrition and immune protection for newborns, crucial for infant development and immune system maturation. Bioactive components protect against infections, and potential modifications to colostrum composition may enhance these immunological benefits. This study evaluated immune mediator stability and the effects of fish oil and/or probiotics supplementation on colostrum composition.
The stability of immune mediators IL-6, IL-8, CCL2, and TNFα were analyzed in a pilot study using bead-based immunoassays. In a randomized double-blind dietary intervention study, pregnant women were assigned to one of four supplementation groups with daily intake beginning early in pregnancy. Colostrum samples were collected from 187 mothers and 16 immune mediators were quantified.
The concentrations of immune mediators showed variation across time points in the pilot study. Surprisingly, IL-6, IL-8, CCL2, and TNFα remained stable, with over 50% retention after 10 days of refrigeration. Supplementation influenced colostrum composition: the fish oil + probiotics group had higher levels of IL-12p70 compared to the probiotics + placebo group, and higher levels of FMS-like tyrosine kinase 3 ligand (FLT-3L) compared to both the fish oil + placebo and probiotics + placebo groups (one-way ANOVA, post-hoc Tukey’s test). Although interferon α2 (IFNα2) levels were higher in the fish oil + probiotics group compared to the fish oil + placebo group. These differences were not statistically significant after correction for multiple comparisons. Overall, fish oil and probiotics supplementation had a modest effect on the concentrations of colostrum immune mediators.
The stability of immune mediators IL-6, IL-8, CCL2, and TNFα were analyzed in a pilot study using bead-based immunoassays. In a randomized double-blind dietary intervention study, pregnant women were assigned to one of four supplementation groups with daily intake beginning early in pregnancy. Colostrum samples were collected from 187 mothers and 16 immune mediators were quantified.
The concentrations of immune mediators showed variation across time points in the pilot study. Surprisingly, IL-6, IL-8, CCL2, and TNFα remained stable, with over 50% retention after 10 days of refrigeration. Supplementation influenced colostrum composition: the fish oil + probiotics group had higher levels of IL-12p70 compared to the probiotics + placebo group, and higher levels of FMS-like tyrosine kinase 3 ligand (FLT-3L) compared to both the fish oil + placebo and probiotics + placebo groups (one-way ANOVA, post-hoc Tukey’s test). Although interferon α2 (IFNα2) levels were higher in the fish oil + probiotics group compared to the fish oil + placebo group. These differences were not statistically significant after correction for multiple comparisons. Overall, fish oil and probiotics supplementation had a modest effect on the concentrations of colostrum immune mediators.